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Sulfoaildenafil (thioaildenafil) is a synthetic chemical compound that is a structural analog of sildenafil (Viagra). 1, it was first reported in sildenafil powder bulk 2005, 2 and it is not approved by any health regulation agency. Like sildenafil, sulfoaildenafil is a phosphodiesterase type 5 inhibitor. Sulfoaildenafil has been found as an adulterant in a variety of supplements which are sold as "natural" or sildenafil powder bulk "herbal" sexual enhancement products. 3 4 5 6, a range of designer analogues of USA FDA-approved inhibitors of type-5 cGMP-specific phosphodiesterase (PDE5 such as sildenafil and vardenafil, have been detected in recent years as adulturants in over-the-counter herbal aphrodisiac products and dietary supplements, 7 8 9 in an apparent. These compounds have been demonstrated to display PDE5 inhibitory activity in vitro and presumably have similar effects when consumed, but have undergone no formal testing in either humans or animals, and as such represent a significant health risk to consumers of these products due. 10, some attempts have been made to ban these drugs side effects of sildenafil as unlicensed medicines, but progress has been slow so far, as even in those jurisdictions which have laws sildenafil powder bulk targeting designer drugs, the laws are drafted to ban analogues of illegal drugs of abuse, rather than. However at least one court case has resulted in a product being taken off the market. 11, in December 2010, the, united States Food and Drug Administration (FDA) issued a warning to consumers about such products stating, "The FDA sildenafil powder bulk has found many products marketed as dietary supplements for sexual enhancement during the past several years that can be harmful because they. See also edit, side effects of sildenafil references edit, gratz, SR; Zeller, M; Mincey, DW; Flurer, CL (2009). "Structural sildenafil powder bulk characterization of sulfoaildenafil, an analog of sildenafil". Journal of pharmaceutical and biomedical analysis. Li, Shuxin; Ren, Jianping; Zhao, Yanjin; Lv, Qiujun; Guo, Jinhua. Pyrazolopyrimidinethione Derivatives, Salts and Solvates thereof, Preparation Methods and Use thereof. WO Gryniewicz, CM; Reepmeyer, JC; Kauffman, JF; Buhse, LF (2009). "Detection of undeclared erectile dysfunction drugs and analogues in dietary supplements by ion mobility spectrometry". FDA warns consumers to avoid sexual enhancement pills, Sanjay Gupta, CNN, December 13th, 2010 Reepmeyer JC, d'Avignon DA (January 2009). "Structure elucidation of thioketone analogues of sildenafil detected as adulterants in herbal aphrodisiacs". Journal of Pharmaceutical and Biomedical Analysis. Balayssac S, Trefi S, Gilard V, Malet-Martino M, Martino R, Delsuc MA (November 2008). "2D and 3D dosy (1)H NMR, a useful tool for analysis of complex mixtures: Application to herbal drugs or dietary supplements for erectile dysfunction". Zou P, Oh SS, Hou P, Low MY, Koh HL (February 2006). "Simultaneous determination of synthetic phosphodiesterase-5 inhibitors found in a dietary supplement and pre-mixed bulk powders for dietary supplements using high-performance liquid chromatography with diode array detection and liquid chromatography-electrospray ionization tandem mass spectrometry". Gratz SR, Gamble BM, Flurer RA (2006). "Accurate mass measurement using Fourier transform ion cyclotron resonance mass spectrometry for structure elucidation of designer drug analogs of tadalafil, vardenafil and sildenafil in herbal and pharmaceutical matrices". Hou P, Zou P, Low MY, Chan E, Koh HL (September 2006). "Structural identification of a new acetildenafil analogue from pre-mixed bulk powder intended as a dietary supplement". Oh, SS; Zou, P; Low, MY; Koh, HL (2006). "Detection of sildenafil analogues in herbal products for erectile dysfunction". Journal of toxicology and environmental health. Venhuis, BJ; Blok-Tip, L; De Kaste, D (2008). "Designer drugs in herbal aphrodisiacs". FDA warns consumers to avoid Man Up Now capsules, United States Food and Drug Administration, Dec. Sildenafil citrate, product name, sildenafil citrate, other name. Viagra, register number (CAS ), molecular formula, c28H38N6O11S, molecular weight 666.7, assay 99 min.

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Viagra, sildenafil, syldenafil (. Sildenafilum) organiczny zwizek chemiczny, lek stosowany w leczeniu zaburze erekcji viagra oraz inne nazwy handlowe) oraz w pierwotnym nadcinieniu pucnym (w tym wskazaniu pod nazw, revatio ). Zosta opatentowany w 1993 roku przez przedsibiorstwo. Pfizer 3 i wprowadzony na rynek w 1998 roku. Nazwa handlowa, viagra wywodzi si z sildenafil citrate wiki sanskryckiego sowa wjaghra ( dewanagari : oznaczajcego tygrysa. Dostpne s te preparaty wardenafilu i tadalafilu o zblionym dziaaniu. Tabletki sildenafilu zawieraj od 25 do 100 miligramw cytrynianu tego zwizku. Mechanizm dziaania sildenafilu polega na hamowaniu enzymu fosfodiesterazy typu 5 pDE5 ) (powinowactwo do innych fosfodiesteraz jest sildenafil citrate wiki znacznie mniejsze: PDE razy, sildenafil citrate wiki PDE 2, 3, 4, sildenafil citrate wiki 7, 8, 9, 10, 11 ponad 700 razy, PDE1 80 razy, PDE6 10 razy). Czsteczka sildenafilu zawiera motyw strukturalny piperazyny oraz analogu nukleozydowej zasady heterocyklicznej, guaniny 1, h -pirazolo4,3- d pirymidyn. Centralny ukad fenolowy jest strukturalnym odpowiednikiem rybozy, natomiast reszta sulfonowa odpowiada grupie fosforanowej nukleotydu. Spis treci U osb ze wskazaniem lekarskim sildenafil umoliwia osignicie trwaego wzwodu umoliwiajcego satysfakcjonujce odbycie stosunku pciowego. Wzwd nie pojawia si automatycznie po zayciu leku, lecz erekcja wymaga zwykej stymulacji seksualnej, co jest wielk jego zalet w porwnaniu z preparatami prostaglandyn. Lek naley spoy od godziny do 6 godzin przed planowanym czasem stosunku. U osb z trudnociami z erekcj lekarz ocenia stopie i charakter tych trudnoci i jeli maj one rzeczywicie charakter psychiczno-neurologiczny, zaleca sildenafil citrate wiki dawk leku, ktra powoduje utrzymywanie si wzwodu przez normalny dla zdrowego mczyzny czas czyli od 30 minut do godziny. Lek nie pomaga osobom, u ktrych trudnoci ze wzwodem maj inny charakter,. Wynikajcy z zaniku cia jamistych prcia lub niskiego cinienia ttniczego. Innym wskazaniem do stosowania sildenafilu s wybrane przypadki nadcinienia pucnego. Wykazano, e sildenafil moe zmniejsza objawy nadcinienia pucnego i poprawia tolerancj wysiku. Stosuje si go wtedy u chorych w rnym wieku wcznie z niemowltami, u ktrych nadcinienie pucne moe powstawa w przebiegu wrodzonych wad serca. Naley jednak pamita o moliwoci powika tego leczenia ze lepot wcznie (vide przeciwwskazania). W badaniu super, udowodniono znamienn popraw wydolnoci wysikowej u pacjentw stosujcych sildenafil w dawce 20, 40 lub 80 miligramw 3 razy na dob i efekt ten by niezaleny od zastosowanej dawki. Sildenafil w dawkach zarejestrowanych do leczenia nadcinienia pucnego nosi nazw Revatio. W dwch duych badaniach klinicznych z randomizacj w grupie 781 kobiet z dysfunkcj seksualn z prawidowym (577 pacjentek) i obnionym (204 pacjentki) steniem estrogenw nie stwierdzono klinicznie istotnej poprawy po przyjmowaniu dawek sildenafilu (10100 mg) w porwnaniu z placebo. Na podstawie drugiego porozumienia konferencji w Princeton 2004 Lek jest przeciwwskazany w nastpujcych chorobach i stanach: Choroba niedokrwienna serca niestabilna lub zaostrzenie dolegliwoci dawicowych, Niekontrolowane cinienie ttnicze, zoliwe nadcinienie ttnicze, Niewydolno krenia klasy nyha III i nyha IV, wieo przebyty zawa serca (do 2 tygodni. Uczulenie na sildenafil, Cika niewydolno wtroby i nerek, Po niedawno przebytym udarze mzgu lub zawale minia sercowego, Zmiany zwyrodnieniowe siatkwki,. Niskie cinienie ttnicze (poniej 90/50 mm Hg) Naley pamita naley, ze omawiany lek obnia cinienie skurczowe rednio o 10. Utrata wzroku w jednym oku w wyniku niettniczej przedniej niedokrwiennej neuropatii nerwu wzrokowego. Mona stosowa z zachowaniem naleytej ostronoci w nastpujcych przypadkach: Choroba niedokrwienna serca stabilna po konsultacji kardiologicznej, Pacjenci w okresie 2 6 tygodni po zawale minia sercowego po konsultacji kardiologicznej, Niewydolno krenia nyha II lub dysfunkcja lewokomorowa, Pacjenci po udarze mzgu, po TIA, z objawami niedokrwienia.

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